The University of California, San Francisco’s Memory and Aging Center provides diagnosis and care for patients with cognitive difficulties and their families. We have a clinical branch and a research branch where we see patients with primary progressive aphasia, as well as patients with aphasia and/or cognitive communication difficulties secondary to a neurodegenerative process (e.g., those with progressive supranuclear palsy syndrome, corticobasal syndrome, Alzheimer’s disease, etc.). We offer observational research opportunities and clinical trials.